![]() One obstacle is that there is an approximate 5☌ difference in temperature between heat applied on the external eyelid surfaces and that which reaches the inner surface of the lids (palpebral conjunctiva), where the meibomian glands are located. Achieving this temperature within the meibomian glands presents several concerns. Previous in vitro and in vivo studies have demonstrated that although the temperatures required to melt the obstructive secretions are reported to range from 32 to 45☌, the more severely obstructed glands present in MGD require temperatures >40☌ for effective liquefaction. This increase results in the need for higher temperatures within the gland to liquefy obstructive material. ![]() However, this therapy can be challenging for many reasons.Ī primary challenge is that MGD alters the molecular composition of the meibum increasing the melting point relative to the normal body temperature. First-line treatment of MGD usually includes some form of heat therapy, attempting to alleviate terminal duct obstruction by liquefaction of the gland contents. The prevalence of aqueous-deficient disease is far exceeded by that of evaporative dry eye, the primary cause of which is meibomian gland dysfunction (MGD), with MGD present in 86% of all dry eye patients of known cause. ![]() Dry eye symptoms are one of the leading reasons why patients seek eye care in the United States. ![]()
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